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Article

Epistatic interactions between modifier genes confer strain-specific redundancy for Tgfb1 in developmental angiogenesis.

Genomics - 1 Jan 2005

Tang Yang, Lee Kyeong Sook, Yang HaiTao, Logan Darren W, Wang Susana, McKinnon Margaret L, Holt Liam J, Condie Alison, Luu Minh Thu, Akhurst Rosemary J

Abstract excerpt

Tgfbm1 (chromosome 5, P = 8 x 10(-5)) and Tgfbm3 (chromosome 12, P = 6 x 10(-11)) were identified as loci that modify developmental angiogenesis of Tgfb1 -/- mice. Congenic mice validated these loci and demonstrated epistatic interaction between them. The novel locus, Tgfbm3, encompasses approximately 22 genes, colocalizes with both tumor susceptibility and atherosclerosis susceptibility loci, and is enriched in...

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Identifiers

PMID: 15607422
DOI: 10.1016/j.ygeno.2004.09.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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