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Article

Genetic variants of Tgfb1 act as context-dependent modifiers of mouse skin tumor susceptibility.

Proceedings of the National Academy of Sciences of the United States of America - 23 May 2006

Mao Jian-Hua, Saunier Elise F, de Koning John P, McKinnon Margaret M, Higgins Mamie Nakijama, Nicklas Kathy, Yang Hai-Tao, Balmain Allan, Akhurst Rosemary J

Abstract excerpt

The human TGFB1 gene is polymorphic, and genetic variants are associated with altered cancer risk. However, human genetic association studies have had variable outcomes because TGFbeta1 action is context-dependent. We used the murine skin model of chemical carcinogenesis in genetic linkage analysis of three independent Mus musculus NIH/Ola x (Mus spretus x M. musculus NIH/Ola)F1 backcrosses, to identify a skin...

Topics

Alleles
Animals
Chromosome Mapping
Crosses, Genetic
Genetic Linkage
Genetic Predisposition to Disease
Genetic Variation
Homozygote
Mice
Polymorphism, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Skin

Skin Neoplasms

Transforming Growth Factor beta

Source

Open in PubMed Open full text

Identifiers

PMID: 16702541
DOI: 10.1073/pnas.0602581103
PMCID: PMC1472440

Genes

TGFB1
SMAD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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