Article

TGF-β1 drives Th9 but not Treg cells upon allergen exposure

2021-08-19

Abstract excerpt

TGF-β1 is known to have a pro-inflammatory impact by inducing Th9 cells, while it also induces anti-inflammatory Treg cells (Tregs). In the context of allergic airway inflammation (AAI) its dual role can be of critical importance in influencing the outcome of the disease. Here we demonstrate that TGF-β acts in AAI by driving effector T cells into Th9 cells, while Tregs differentiate independently. Induction of exp...

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Literature Corpus work: b5b236f0-2f89-54d3-ab24-d8c6d25ea284
DOI: 10.1101/2021.08.18.456797

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