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Article

STAT3 polymorphism can predict the response to interferon-α therapy in patients with metastatic renal cell carcinoma.

European urology - 1 Apr 2013

Eto Masatoshi, Kamba Tomomi, Miyake Hideaki, Fujisawa Masato, Kamai Takao, Uemura Hirotsugu, Tsukamoto Taiji, Azuma Haruhito, Matsubara Akio, Nishimura Kazuo, Nakamura Tsuyoshi, Ogawa Osamu, Naito Seiji

Abstract excerpt

BACKGROUND: In our 2007 retrospective study, we reported that single nucleotide polymorphisms (SNPs) in the signal transducer and activator of transcription 3 (acute-phase response factor) (STAT3) gene were significantly associated with better response to interferon (IFN)-α in patients with metastatic renal cell carcinoma (mRCC). OBJECTIVE: To prospectively confirm those results, the Japan Immunotherapy...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23063454
DOI: 10.1016/j.eururo.2012.09.052

Genes

STAT3
PTGS1
PTGS2
SOCS3
TAP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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