Article
Prognosis of metastatic renal cell carcinoma with first-line interferon-α therapy in the era of molecular-targeted therapy.
Cancer science - 1 Jul 2016
Kawano Yoshiaki, Takahashi Wataru, Eto Masatoshi, Kamba Tomomi, Miyake Hideaki, Fujisawa Masato, Kamai Takao, Uemura Hirotsugu, Tsukamoto Taiji, Azuma Haruhito, Matsubara Akio, Nishimura Kazuo, Nakamura Tsuyoshi, Ogawa Osamu, Naito Seiji
Abstract excerpt
The RCC-SELECT study showed the correlation between single nucleotide polymorphisms (SNP) in STAT3 gene and survival in metastatic renal cell carcinoma (mRCC) patients with first-line interferon-α (IFN-α). In that study, even patients with STAT3 SNP linked to shorter overall survival (OS) exhibited remarkably improved prognosis. All 180 patients evaluated in the above study were further analyzed for correlation...
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