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Article

Human apolipoprotein E4 accelerates beta-amyloid deposition in APPsw transgenic mouse brain.

Annals of neurology - 1 Oct 2001

Carter D B, Dunn E, McKinley D D, Stratman N C, Boyle T P, Kuiper S L, Oostveen J A, Weaver R J, Boller J A, Gurney M E

Abstract excerpt

The human apolipoprotein E4 (ApoE4) isoform is associated with genetic risk for Alzheimer's disease. To assess the effects of different ApoE isoforms on amyloid plaque formation, human ApoE3 and ApoE4 were expressed in the brains of transgenic mice under the control of the human transferrin promoter. Mice were crossed with transgenic mice expressing human amyloid precursor protein containing the Swedish mutation...

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Source

Identifiers

PMID: 11601499
DOI: 10.1002/ana.1134

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Human apolipoprotein E4 accelerates beta-amyloid deposition in APPsw transgenic mouse brain.PMID 11601499Read ↗

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Murine versus human apolipoprotein E4: differential facilitation of and co-localization in cerebral amyloid angiopathy and amyloid plaques in APP transgenic mouse models.Semantic proximity Read ↗

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