Article
Human apolipoprotein E4 accelerates beta-amyloid deposition in APPsw transgenic mouse brain.
Annals of neurology - 1 Oct 2001
Carter D B, Dunn E, McKinley D D, Stratman N C, Boyle T P, Kuiper S L, Oostveen J A, Weaver R J, Boller J A, Gurney M E
Abstract excerpt
The human apolipoprotein E4 (ApoE4) isoform is associated with genetic risk for Alzheimer's disease. To assess the effects of different ApoE isoforms on amyloid plaque formation, human ApoE3 and ApoE4 were expressed in the brains of transgenic mice under the control of the human transferrin promoter. Mice were crossed with transgenic mice expressing human amyloid precursor protein containing the Swedish mutation...
Topics
- Age Factors
- Amyloid beta-Peptides
- Amyloid beta-Protein Precursor
- Animals
- Antibodies, Monoclonal
- Apolipoprotein E4
- Apolipoproteins E
- Brain
- Brain Chemistry
- Gene Expression
- Humans