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Article

Amyloid-β42 alters apolipoprotein E solubility in brains of mice with five familial AD mutations.

Journal of neuroscience methods - 15 Mar 2011

Youmans Katherine Lynn, Leung Steffi, Zhang Juan, Maus Erika, Baysac Kathleen, Bu Guojun, Vassar Robert, Yu Chunjiang, LaDu Mary Jo

Abstract excerpt

Amyloid plaques composed of the 42 amino acid form of amyloid-β peptide (Aβ42) are a pathological hallmark of Alzheimer's disease (AD), but soluble and intraneuronal Aβ42 are the more proximal causes of synaptic dysfunction and neurotoxicity. Apolipoprotein E (apoE) modulates this disease process, as inheritance of the ɛ4 allele of the apoE gene is the primary genetic risk factor for AD. To address the solubility...

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Identifiers

PMID: 21219931
DOI: 10.1016/j.jneumeth.2010.12.025
PMCID: PMC3049315

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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