Article
ALK expressed in a gastrointestinal stromal tumor harboring PDGFRA p. D842V mutation:a case report.
Diagnostic pathology - 31 Jan 2020
Fan Jun, Yang Ming, Huang Bo, Wang Zhenkao, Luo Danju, Zhang Jiwei, Zhang Peng, Shi Heshui, Li Yan, Nie Xiu
Abstract excerpt
BACKGROUND: Gastrointestinal stromal tumors (GISTs) are the most common type of adult mesenchymal neoplasms. The events that drive GIST oncogenesis are primarily KIT or PDGFRA mutations, which lead to the susceptibility of these tumors to small-molecule tyrosine kinase inhibitors such as imatinib and sunitinib. However, previous studies have shown that patients with a PDGFRA D842V mutation in GISTs have a very...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.