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Article

Gastrointestinal Stromal Tumor: History, Molecular Subtypes, and Risk Stratification.

Journal of gastric cancer - 1 Apr 2026

Song In Hye, Ahn Soomin, Kim Hyung-Don, Jo Jeong-Hyeon, Shin Jinho, Ryu Min-Hee, Park Young Soo

Abstract excerpt

The gastrointestinal stromal tumor (GIST) is one of the most common mesenchymal tumors of the gastrointestinal tract. Between the 1990s and early 2000s, GIST was identified as a tumor characterized by KIT or PDGFRA mutations, resulting in imatinib being established as an effective targeted therapy. However, with advances in molecular diagnostics, approximately 10%-15% of GISTs have been reported to harbor...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41942355
DOI: 10.5230/jgc.2026.26.e7
PMCID: PMC13053826

Genes

BRAF
KIT
PDGFRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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