Article
[Forkhead-box-O1 locus and metabolic markers in the elderly: an association study].
Revista espanola de geriatria y gerontologia - 1 Jan 2000
Paroni Giulia, Addante Filomena, Seripa Davide, Panza Francesco, Copetti Massimiliano, Fontana Luigi, Pilotto Alberto
Abstract excerpt
INTRODUCTION: Mutations of forkhead-box-O1 (FOXO1) gene at locus 13q14.1 cause changes in biochemical parameters leading to premature aging. Protein FoxO1 participates in the regulation of biochemical pathways, including those influencing the regulation of lipid profile and glucose metabolism. These parameters are a risk factor for all-cause mortality in the elderly population. The aim of this study was to...
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