Genetic analysis of the subunit organization and function of the conserved oligomeric golgi (COG) complex: studies of COG5- and COG7-deficient mammalian cells.

doi:10.1074/jbc.M505558200

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Article

Genetic analysis of the subunit organization and function of the conserved oligomeric golgi (COG) complex: studies of COG5- and COG7-deficient mammalian cells.

The Journal of biological chemistry - 23 Sept 2005

Oka Toshihiko, Vasile Eliza, Penman Marsha, Novina Carl D, Dykxhoorn Derek M, Ungar Daniel, Hughson Frederick M, Krieger Monty

Abstract excerpt

The conserved oligomeric Golgi (COG) complex is an eight-subunit (Cog1-8) peripheral Golgi protein involved in Golgi-associated membrane trafficking and glycoconjugate synthesis. We have analyzed the structure and function of COG using Cog1 or Cog2 null Chinese hamster ovary cell mutants, fibroblasts from a patient with Cog7-deficient congenital disorders of glycosylation, and stable Cog5-deficient HeLa cells...

Topics

Adaptor Proteins, Vesicular Transport
Animals
Arachis
CHO Cells
Carrier Proteins
Chromatography, Gel
Cricetinae
Fibroblasts
Golgi Apparatus
HeLa Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Immunoblotting

Immunoprecipitation

Lectins

Membrane Proteins

Microscopy, Electron

Microscopy, Fluorescence

Models, Biological

Source

Open in PubMed

Identifiers

PMID: 16051600
DOI: 10.1074/jbc.M505558200

Genes

COG5
COG7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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Genetic analysis of the subunit organization and function of the conserved oligomeric golgi (COG) complex: studies of COG5- and COG7-deficient mammalian cells.PMID 16051600Read ↗

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