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Article

Human surfactant protein A2 gene mutations impair dimmer/trimer assembly leading to deficiency in protein sialylation and secretion.

PloS one - 1 Jan 2012

Song Yi, Fang Guodong, Shen Haitao, Li Hui, Yang Wenbing, Pan Bing, Huang Guowei, Lin Guangyu, Ma Lian, Willard Belinda, Gu Jiang, Zheng Lemin, Wang Yongyu

Abstract excerpt

Surfactant protein A2 (SP-A2) plays an essential role in surfactant metabolism and lung host defense. SP-A2 mutations in the carbohydrate recognition domain have been related to familial pulmonary fibrosis and can lead to a recombinant protein secretion deficiency in vitro. In this study, we explored the molecular mechanism of protein secretion deficiency and the subsequent biological effects in CHO-K1 cells...

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Identifiers

PMID: 23056344
DOI: 10.1371/journal.pone.0046559
PMCID: PMC3463533

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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