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Article

Surfactant Protein (SP)-A Benefits Over SP-A Mutant: A Preliminary Study for Interstitial Lung Disease Treatment.

American journal of respiratory cell and molecular biology - 1 Dec 2025

Desroziers Tifenn, Soreze Yohan, Legendre Marie, Dastot Le Moal Florence, Nau Valérie, Amselem Serge, Giurgea Irina, Karabina Sonia, Louvrier Camille, Nathan Nadia

Abstract excerpt

Surfactant protein (SP)-A, an octadecamer composed of SP-A1 and SP-A2, is secreted into the alveolar space. Heterozygous variations in SFTPA1 and SFTPA2, reported to impair protein secretion, have been associated with interstitial lung disease and lung adenocarcinoma. To date, no specific treatment is available. Here, the impact of wild-type (WT) SP-A1 or SP-A2 on the localization, oligomerization, and secretion...

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Source

Identifiers

PMID: 40591931
DOI: 10.1165/rcmb.2024-0546OC

Genes

SFTPA1
SFTPA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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