Article

Divergent Pathways of Surfactant Protein C Maturation for Disease-Associated Isoforms

2025-10-04

Abstract excerpt

<h4>ABSTRACT</h4> Surfactant Protein C (SP-C), a hydrophobic protein exclusively synthesized and secreted by alveolar type II (AT2) cells, is important for reducing alveolar surface tension in the distal lung. Chronic interstitial pulmonary diseases have been associated with SFTPC mutations. However, a detailed understanding of SP-C maturation in the secretory pathway and disruptions caused by mutations has rema...

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Literature Corpus work: 94b19f7f-eaad-5832-9ce7-1f6b4bb4411b
DOI: 10.1101/2025.10.03.679829

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