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Article

Characterization and classification of ATP-binding cassette transporter ABCA3 mutants in fatal surfactant deficiency.

The Journal of biological chemistry - 10 Nov 2006

Matsumura Yoshihiro, Ban Nobuhiro, Ueda Kazumitsu, Inagaki Nobuya

Abstract excerpt

The ATP-binding cassette transporter ABCA3 is expressed predominantly at the limiting membrane of the lamellar bodies in lung alveolar type II cells. Recent study has shown that mutation of the ABCA3 gene causes fatal surfactant deficiency in newborns. In this study, we investigated in HEK293 cells the intracellular localization and N-glycosylation of the ABCA3 mutants so far identified in fatal surfactant...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16959783
DOI: 10.1074/jbc.M600071200

Genes

ABCA3
LAMP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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