Article
Disruption of N-linked glycosylation promotes proteasomal degradation of the human ATP-binding cassette transporter ABCA3.
American journal of physiology. Lung cellular and molecular physiology - 1 Dec 2013
Beers Michael F, Zhao Ming, Tomer Yaniv, Russo Scott J, Zhang Peggy, Gonzales Linda W, Guttentag Susan H, Mulugeta Surafel
Abstract excerpt
The lipid transport protein, ABCA3, expressed in alveolar type 2 (AT2) cells, is critical for surfactant homeostasis. The first luminal loop of ABCA3 contains three putative N-linked glycosylation sites at residues 53, 124, and 140. A common cotranslational modification, N-linked glycosylation, is critical for the proper expression of glycoproteins by enhancing folding, trafficking, and stability through...
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