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Article

Role of N-glycosylation of surfactant protein SP-BN in lipid and SP-B interacting properties. Implications in disease.

American journal of physiology. Lung cellular and molecular physiology - 1 May 2025

Isasi-Campillo Miriam, Rangel-Arranz Paula, García-Ortega Lucía, Pérez-Gil Jesús

Abstract excerpt

SP-BN is an independent protein derived from the precursor of pulmonary surfactant protein B (SP-B), a critical component of the pulmonary surfactant (PS), the membrane-based system that coats the alveolar air-liquid interface and is essential for both respiratory mechanics and innate defense. In humans, a single-nucleotide polymorphism (SNP) defining hSP-BN glycosylation has been associated with propensity to...

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PMID: 40214202
DOI: 10.1152/ajplung.00350.2024

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