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Article

Surfactant protein A2 mutations associated with pulmonary fibrosis lead to protein instability and endoplasmic reticulum stress.

The Journal of biological chemistry - 16 Jul 2010

Maitra Meenakshi, Wang Yongyu, Gerard Robert D, Mendelson Carole R, Garcia Christine Kim

Abstract excerpt

Rare heterozygous mutations in the gene encoding surfactant protein A2 (SP-A2, SFTPA2) are associated with adult-onset pulmonary fibrosis and adenocarcinoma of the lung. We have previously shown that two recombinant SP-A2 mutant proteins (G231V and F198S) remain within the endoplasmic reticulum (ER) of A549 cells and are not secreted into the culture medium. The pathogenic mechanism of the mutant proteins is...

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Identifiers

PMID: 20466729
DOI: 10.1074/jbc.M110.121467
PMCID: PMC2903395

Genes

SFTPA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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