Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic variation in SP-A2 leads to differential binding to Mycoplasma pneumoniae membranes and regulation of host responses.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2015

Ledford Julie G, Voelker Dennis R, Addison Kenneth J, Wang Ying, Nikam Vinayak S, Degan Simone, Kandasamy Pitachaimani, Tanyaratsrisakul Sasipa, Fischer Bernard M, Kraft Monica, Hollingsworth John W

Abstract excerpt

Mycoplasma pneumoniae is an extracellular pathogen that colonizes mucosal surfaces of the respiratory tract and is associated with asthma exacerbations. Previous reports demonstrate that surfactant protein-A (SP-A) binds live M. pneumoniae and mycoplasma membrane fractions (MMF) with high affinity. Humans express a repertoire of single-amino acid genetic variants of SP-A that may be associated with lung disease,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chemotaxis
Share to Gene Order

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mucin 5AC

Share to Mycoplasma pneumoniae

Share to Neutrophils

Share to Pneumonia, Mycoplasma

Share to Pulmonary Surfactant-Associated Protein A

Source

Open in PubMed Open full text

Identifiers

PMID: 25957169
DOI: 10.4049/jimmunol.1500104
PMCID: PMC4458406

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variation in SP-A2 leads to differential binding to Mycoplasma pneumoniae membranes and regulation of host responses.PMID 25957169Read ↗

Human Surfactant Protein SP-A1 and SP-A2 Variants Differentially Affect the Alveolar Microenvironment, Surfactant Structure, Regulation and Function of the Alveolar Macrophage, and Animal and Human Survival Under Various Conditions.Semantic proximity Read ↗

Differential effects of innate immune variants of surfactant protein-A1 (SFTPA1) and SP-A2 (SFTPA2) in airway function after Klebsiella pneumoniae infection and sex differences.Semantic proximity Read ↗

Survival of Surfactant Protein-A1 and SP-A2 Transgenic Mice After Klebsiella pneumoniae Infection, Exhibits Sex-, Gene-, and Variant Specific Differences; Treatment With Surfactant Protein Improves SurvivalSemantic proximity Read ↗

Genetic Complexity of the Human Innate Host Defense Molecules, Surfactant Protein A1 (SP-A1) and SP-A2Impact on FunctionSemantic proximity Read ↗

Surfactant Protein (SP)-A Benefits Over SP-A Mutant: A Preliminary Study for Interstitial Lung Disease Treatment.Semantic proximity Read ↗

Differences In The Alveolar Macrophage Proteome In Transgenic Mice Expressing Human SP-A1 And SP-A2Semantic proximity Read ↗

SURFACTANT PROTEIN A: AN INNATE IMMUNE MODULATOR AND THERAPEUTIC IN ASTHMA.Semantic proximity Read ↗

Differential Impact of Co-expressed SP-A1/SP-A2 Protein on AM miRNome; Sex DifferencesSemantic proximity Read ↗

Identification and Characterization of Human Surfactant Protein A Binding Protein of<i>Mycoplasma pneumoniae</i>Semantic proximity Read ↗

Genetic variation in surfactant protein-A2 alters responses to ozone.Semantic proximity Read ↗

Genetic Diversity of Human SP-A, a Molecule with Innate host Defense and Surfactant-Related Functions; Characteristics, Primary Function, and Significance.Semantic proximity Read ↗

Differential susceptibility of transgenic mice expressing human surfactant protein B genetic variants to Pseudomonas aeruginosa induced pneumonia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.