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Article

Structural Basis of Alcohol Inhibition of the Pentameric Ligand-Gated Ion Channel ELIC.

Structure (London, England : 1993) - 3 Jan 2017

Chen Qiang, Wells Marta M, Tillman Tommy S, Kinde Monica N, Cohen Aina, Xu Yan, Tang Pei

Abstract excerpt

The structural basis for alcohol modulation of neuronal pentameric ligand-gated ion channels (pLGICs) remains elusive. We determined an inhibitory mechanism of alcohol on the pLGIC Erwinia chrysanthemi (ELIC) through direct binding to the pore. X-ray structures of ELIC co-crystallized with 2-bromoethanol, in both the absence and presence of agonist, reveal 2-bromoethanol binding in the pore near T237(6') and the...

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Identifiers

PMID: 27916519
DOI: 10.1016/j.str.2016.11.007
PMCID: PMC5214846

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ECD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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