Article
A naturally occurring variant in human TLR9, P99L, is associated with loss of CpG oligonucleotide responsiveness.
The Journal of biological chemistry - 19 Nov 2010
Kubarenko Andriy V, Ranjan Satish, Rautanen Anna, Mills Tara C, Wong Sunny, Vannberg Fredrik, Neumaier Michael, Bekeredjian-Ding Isabelle, Hill Adrian V S, Ahmad-Nejad Parviz, Weber Alexander N R
Abstract excerpt
The innate immune system employs Toll-like receptors (TLRs) for the detection of invading microorganisms based on distinct molecular patterns. For example, TLR9 is activated by microbial DNA and also by short therapeutic CpG-containing oligonucleotides (CpG-ODN). TLR9 activation leads to the production of interferons and the priming of humoral adaptive immune responses. Unfortunately, the principles of ligand...
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