Overlapping structure of hepatitis B virus (HBV) genome and immune selection pressure are critical forces modulating HBV evolution.

doi:10.1099/vir.0.046524-0

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Article

Overlapping structure of hepatitis B virus (HBV) genome and immune selection pressure are critical forces modulating HBV evolution.

The Journal of general virology - 1 Jan 2013

Cento Valeria, Mirabelli Carmen, Dimonte Salvatore, Salpini Romina, Han Yue, Trimoulet Pascale, Bertoli Ada, Micheli Valeria, Gubertini Guido, Cappiello Giuseppina, Spanò Alberto, Longo Roberta, Bernassola Martina, Mazzotta Francesco, De Sanctis Giuseppe Maria, Zhang Xin Xin, Verheyen Jens, D'Arminio Monforte Antonella, Ceccherini-Silberstein Francesca, Perno Carlo Federico, Svicher Valentina

Abstract excerpt

How the overlap between the hepatitis B virus (HBV) reverse transcriptase (RT) and HBV S antigen (HBsAg) genes modulates the extent of HBV genetic variability is still an open question, and was investigated here. The rate of nucleotide conservation (≤1% variability) followed an atypical pattern in the RT gene, due to an overlap between RT and HBsAg (69.9% nucleotide conservation in the overlapping region vs 41.2%...

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Identifiers

PMID: 23052389
DOI: 10.1099/vir.0.046524-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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