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Article

Immune-induced evolutionary selection focused on a single reading frame in overlapping hepatitis B virus proteins.

Journal of virology - 1 May 2011

Maman Yaakov, Blancher Antoine, Benichou Jennifer, Yablonka Adi, Efroni Sol, Louzoun Yoram

Abstract excerpt

Viruses employ various means to evade immune detection. Reduction of CD8(+) T cell epitopes is one of the common strategies used for this purpose. Hepatitis B virus (HBV), a member of the Hepadnaviridae family, has four open reading frames, with about 50% overlap between the genes they encode. We computed the CD8(+) T cell epitope density within HBV proteins and the mutations within the epitopes. Our results...

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Share to CD8-Positive T-Lymphocytes
Share to DNA-Directed DNA Polymerase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21307195
DOI: 10.1128/JVI.02142-10
PMCID: PMC3126273

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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