Article
Influence of overlapping genes on the evolution of human hepatitis B virus.
Virology - 20 Jun 2013
Torres Carolina, Fernández María Dolores Blanco, Flichman Diego Martín, Campos Rodolfo Héctor, Mbayed Viviana Andrea
Abstract excerpt
The aim of this work was to analyse the influence of overlapping genes on the evolution of hepatitis B virus (HBV). A differential evolutionary behaviour among genetic regions and clinical status was found. Dissimilar levels of conservation of the different protein regions could derive from alternative mechanisms to maintain functionality. We propose that, in overlapping regions, selective constraints on one of...
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