Article
HBV S antigen evolution in the backdrop of HDV infection affects epitope processing and presentation.
Journal of medical virology - 1 Jun 2021
Sajjad Mehwish, Ali Syed, Baig Samina, Sharafat Shaheen, Khan Bilal Ahmed, Khan Saeed, Mughal Nouman, Abidi Syed Hani
Abstract excerpt
INTRODUCTION: HBV can evolve under selection pressure exerted by drugs and/or host immunity, resulting in accumulation of escape mutations that can affect the drug or the immune activity. Hepatitis delta virus (HDV) coinfection is also known to exert selection pressure on HBV, which leads to selective amplification of certain mutations, especially in genes that are required for HDV pathogenesis, such as HBsAg....
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