Article
Higher detection rates of amino acid substitutions in HBV reverse transcriptase/surface protein overlapping sequence is correlated with lower serum HBV DNA and HBsAg levels in HBeAg-positive chronic hepatitis B patients with subgenotype B2.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Jun 2016
Su Mingze, Xiang Kuanhui, Li Yao, Li Yutang, Deng Juan, Xu Xizhan, Yan Ling, Zhuang Hui, Li Tong
Abstract excerpt
OBJECTIVES: Hepatitis B virus (HBV) subgenotype B2 is prevalent in China and some other parts of Asia. This study aimed to carry out a subgenotype B2 specific mutation analysis on important amino acid (AA) sites in overlapping reverse transcriptase (RT) and surface (S) protein coding regions of HBV. MATERIALS AND METHODS: A total of 143 hepatitis B e antigen (HBeAg)-positive chronic hepatitis B (CHB) patients...
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