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Article

Impaired G protein coupling of the neurotensin receptor 1 by mutations in extracellular loop 3.

European journal of pharmacology - 14 Dec 2001

Richard F, Barroso S, Nicolas-Ethève D, Kitabgi P, Labbé-Jullié C

Abstract excerpt

The neurotensin receptor 1, NTS1, is a G protein-coupled receptor. We have shown previously that the NTS1 receptor-binding site of the peptide agonist involved residues in extracellular loop 3 and at the extracellular junction of transmembrane domains 4 and 6. Here, we investigated by site-directed mutagenesis residues in extracellular loop 3 that might be involved in agonist-induced activation of the rat NTS1...

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PMID: 11755135
DOI: 10.1016/s0014-2999(01)01496-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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