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Article

Peptide backbone modifications on the C-terminal hexapeptide of neurotensin.

Bioorganic & medicinal chemistry letters - 15 Mar 2008

Einsiedel Jürgen, Hübner Harald, Hervet Maud, Härterich Steffen, Koschatzky Susanne, Gmeiner Peter

Abstract excerpt

To compare backbone-induced susceptibilities with affinity changes that are caused by side-chain modifications in the respective positions, structure activity relationship studies on a series of NT(8-13) analogues were performed providing valuable insights into the major requirement for neurotensin receptor recognition and activation. The data led us to highly potent NTR1 ligands and the generation of a...

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PMID: 18276136
DOI: 10.1016/j.bmcl.2008.01.110

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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