Article
Inhibition of MEL cells' capacity to undergo erythroid differentiation by chemicals added during induction.
Mutation research - 1 Feb 1990
Foresti M, Gaudio L, Geraci G
Abstract excerpt
Erythroid differentiation of murine erythroleukemia (MEL) cells, as induced by dimethyl sulfoxide, can be suppressed by chemicals at very low concentrations, not affecting cell viability and proliferation, if present in the culture medium between 18 and 24 h after addition of the inducer. The eff...
Topics
- Cell Differentiation
- DNA
- Dimethyl Sulfoxide
- Erythroid Precursor Cells
- Interphase
- Methylation
- Mutagens
- Phenotype
- Structure-Activity Relationship
- Tumor Cells, Cultured