Evolution of a mutant J2E erythroid cell line which does not respond to erythropoietin.

Article

Evolution of a mutant J2E erythroid cell line which does not respond to erythropoietin.

Leukemia - 1 Jan 1990

Klinken S P, Nicola N A

Abstract excerpt

The recently derived J2E cell lines differentiate in response to erythropoietin. However, during the course of growth in culture, a subclone has emerged which fails to synthesize hemoglobin or show accelerated proliferation following hormonal stimulation. The inability to respond to erythropoieti...

Topics

Animals
Cell Line, Transformed
Erythropoietin
Hemoglobins
Mice
Mutation
Oncogenes
RNA
Receptors, Cell Surface
Receptors, Erythropoietin

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