Article
Correlation between levels of delta protein kinase C and resistance to differentiation in murine erythroleukemia cells.
Biochemical and biophysical research communications - 7 Mar 1996
Patrone M, Pessino A, Passalacqua M, Sparatore B, Melloni E, Pontremoli S
Abstract excerpt
It has been demonstrated that the level of delta protein kinase C is inversely correlated to the responsiveness of murine erythroleukemia cells to chemical induction to terminal erythroid differentiation. In these cells, deltaPKC is largely present in a membrane associated form, and thus in a constitutively active state, a condition which characterizes the undifferentiated phenotype. Accordingly, commitment to...
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