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Article

Cyclin D1 Activity Regulates Autophagy and Senescence in the Mammary Epithelium

6 Oct 2012

Abstract excerpt

Overexpression of cyclin D1 is believed to endow mammary epithelial cells (MEC) with a proliferative advantage by virtue of its contribution to pRB inactivation. Accordingly, abrogation of the kinase-dependent function of cyclin D1 is sufficient to render mice resistant to breast cancer initiated by ErbB2. Here, we report that mouse cyclin D1(KE/KE) MECs (deficient in cyclin D1 activity) upregulate an...

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PMID: 23041550
DOI: 10.1158/0008-5472.can-11-4139

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