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Article

Cyclin D1-dependent kinase activity in murine development and mammary tumorigenesis.

Cancer cell - 1 Jan 2006

Landis Mark W, Pawlyk Basil S, Li Tiansen, Sicinski Piotr, Hinds Philip W

Abstract excerpt

Cyclin D1 is a multifunctional protein that activates CDK4 and CDK6, titrates Cip/Kip CDK inhibitors to increase CDK2 activity, and modulates the function of certain transcription factors. To specifically test the importance of cyclin D1-associated kinase activity, we generated "knockin" mice expressing mutant cyclin D1 deficient in activating CDK4/6. The development of several cyclin D1-dependent compartments,...

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Share to Cyclin D1
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, erbB-2

Share to Mammary Glands, Animal

Share to Mammary Neoplasms, Experimental

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Source

Identifiers

PMID: 16413468
DOI: 10.1016/j.ccr.2005.12.019

Genes

CDK4
CDK2
CDK6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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