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Article

CDK4/6 Dependence of Cyclin D1-Driven Parathyroid Neoplasia in Transgenic Mice.

Endocrinology - 1 Oct 2020

Costa-Guda Jessica, Corrado Kristin, Bellizzi Justin, Romano Robert, Saria Elizabeth, Saucier Kirsten, Rose Madison, Shah Samip, Alander Cynthia, Mallya Sanjay, Arnold Andrew

Abstract excerpt

The protein product of the cyclin D1 oncogene functions by activating partner cyclin-dependent kinases (cdk)4 or cdk6 to phosphorylate, thereby inactivating, the retinoblastoma protein pRB. Nonclassical, cdk-independent, functions of cyclin D1 have been described but their role in cyclin D1-driven neoplasia, with attendant implications for recently approved cdk4/6 chemotherapeutic inhibitors, requires further...

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Source

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Identifiers

PMID: 32877917
DOI: 10.1210/endocr/bqaa159
PMCID: PMC7521127

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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