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Article

Rheb1-Independent Activation of mTORC1 in Mammary Tumors Occurs through Activating Mutations in mTOR.

Cell reports - 28 Apr 2020

Xiao Bin, Zuo Dongmei, Hirukawa Alison, Cardiff Robert D, Lamb Richard, Sonenberg Nahum, Muller William J

Abstract excerpt

Mechanistic target of rapamycin complex 1 (mTORC1) is a master modulator of cellular growth, and its aberrant regulation is recurrently documented within breast cancer. While the small GTPase Rheb1 is the canonical activator of mTORC1, Rheb1-independent mechanisms of mTORC1 activation have also been reported but have not been fully understood. Employing multiple transgenic mouse models of breast cancer, we report...

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Identifiers

PMID: 32348753
DOI: 10.1016/j.celrep.2020.107571
PMCID: PMC7281837

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