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Article

Cooperation between Dmp1 loss and cyclin D1 overexpression in breast cancer.

The American journal of pathology - 1 Oct 2013

Zhu Sinan, Mott Ryan T, Fry Elizabeth A, Taneja Pankaj, Kulik George, Sui Guangchao, Inoue Kazushi

Abstract excerpt

Cyclin D1 is a component of the core cell-cycle machinery and is frequently overexpressed in breast cancer. It physically interacts with the tumor suppressor Dmp1 that attenuates the oncogenic signals from Ras and HER2 by inducing Arf/p53-dependent cell-cycle arrest. Currently, the biological significance of Dmp1-cyclin D1 interplay in breast cancer has not been determined. Here, we show that cyclin D1 bound to...

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Share to Carcinogenesis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mammary Neoplasms, Experimental

Share to Mammary Tumor Virus, Mouse

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Source

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Identifiers

PMID: 23938323
DOI: 10.1016/j.ajpath.2013.06.027
PMCID: PMC3791682

Genes

DMP1

Provenance

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