Article
The synergy of -260T T CD14 and -308GG TNF-α genotypes in survival of critically ill patients.
Scandinavian journal of immunology - 1 Jan 2013
Fallavena P R V, de Jesus Borges T, Paskulin D D, Thurow H S, de Oliveira Paludo F J, Dos Santos Froes C, Graebin P, Dias F S, de Toledo Nóbrega O, Alho C S
Abstract excerpt
Literature suggests that the analysis of several polymorphic genetic markers is more informative than the analysis of a single polymorphism. In this study, we tested whether the shared inheritance of TLR2 and TLR4 and TNF-α allelic variants may act in synergy with -260C>T CD14 SNP on the outcome from critical conditions. We monitored 524 critically ill patients from South Brazilian, daily from the ICU admission...
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