The CD14 rs2569190 TT Genotype Is Associated with an Improved 30-Day Survival in Patients with Sepsis: A Prospective Observational Cohort Study.

doi:10.1371/journal.pone.0127761

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Article

The CD14 rs2569190 TT Genotype Is Associated with an Improved 30-Day Survival in Patients with Sepsis: A Prospective Observational Cohort Study.

PloS one - 1 Jan 2015

Mansur Ashham, Liese Benjamin, Steinau Maximilian, Ghadimi Michael, Bergmann Ingo, Tzvetkov Mladen, Popov Aron Frederik, Beissbarth Tim, Bauer Martin, Hinz José

Abstract excerpt

According to previous investigations, CD14 is suggested to play a pivotal role in initiating and perpetuating the pro-inflammatory response during sepsis. A functional polymorphism within the CD14 gene, rs2569190, has been shown to impact the pro-inflammatory response upon stimulation with lipopolysaccharide, a central mediator of inflammation in sepsis. In this study, we hypothesized that the strong...

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PMID: 26020644
DOI: 10.1371/journal.pone.0127761
PMCID: PMC4447461

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