Article
Effect of CD14 -260C>T polymorphism on the mortality of critically ill patients.
Immunology and cell biology - 1 Aug 2006
D'Avila Luiz C, Albarus Maria H, Franco Carolina R, Aguiar Bibiana B, Oliveira Jarbas R, Dias Fernando S, Alho Clarice S
Abstract excerpt
The CD14 receptor seems to be an important part of the innate immune system. A mutant CD14 can produce a reduced signal in response to infection, as a result of which an adequate inflammatory innate response is not induced, leading to a systemic infection. Defects in the innate immunity increase patient susceptibility to systemic infections and can produce a deregulated inflammatory response causing sepsis, organ...
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