Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Wapl antagonizes cohesin binding and promotes Polycomb-group silencing in Drosophila.

Development (Cambridge, England) - 1 Nov 2012

Cunningham Melissa D, Gause Maria, Cheng Yuzhong, Noyes Amanda, Dorsett Dale, Kennison James A, Kassis Judith A

Abstract excerpt

Wapl protein regulates binding of the cohesin complex to chromosomes during interphase and helps remove cohesin from chromosomes at mitosis. We isolated a dominant mutation in wapl (wapl(AG)) in a screen for mutations that counteract silencing mediated by an engrailed Polycomb-group response element. wapl(AG) hemizygotes die as pharate adults and have an extra sex combs phenotype characteristic of males with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Codon, Nonsense
Share to Chromosomal Proteins, Non-Histone

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drosophila

Share to Drosophila Proteins

Share to Gene Expression Regulation, Developmental

Share to Gene Silencing

Share to Homeodomain Proteins

Share to Polycomb Repressive Complex 1

Source

Open in PubMed Open full text

Identifiers

PMID: 23034634
DOI: 10.1242/dev.084566
PMCID: PMC3478686

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Wapl antagonizes cohesin binding and promotes Polycomb-group silencing in Drosophila.PMID 23034634Read ↗

Genetic and molecular analysis of wings apart-like (wapl), a gene controlling heterochromatin organization in Drosophila melanogaster.Semantic proximity Read ↗

Brca2, Pds5 and Wapl differentially control cohesin chromosome association and functionSemantic proximity Read ↗

Analysis of a polycomb group protein defines regions that link repressive activity on nucleosomal templates to in vivo function.Semantic proximity Read ↗

Structure of the human cohesin inhibitor Wapl.Semantic proximity Read ↗

Dynamic regulation by polycomb group protein complexes controls pattern formation and the cell cycle in Drosophila.Semantic proximity Read ↗

Decreasing <i>Wapl</i> dosage partially corrects transcriptome phenotypes in <i>Nipbl</i> -/+ embryonic mouse brainSemantic proximity Read ↗

The polycomb group mutant esc leads to augmented levels of paused Pol II in the Drosophila embryo.Semantic proximity Read ↗

Screen for enhancers of Polycomb and Polycomblike in Drosophila melanogaster.Semantic proximity Read ↗

Budding yeast Wpl1(Rad61)-Pds5 complex counteracts sister chromatid cohesion-establishing reaction.Semantic proximity Read ↗

RNAi components are required for nuclear clustering of Polycomb group response elements.Semantic proximity Read ↗

Pds5 promotes cohesin acetylation and stable cohesin-chromosome interaction.Semantic proximity Read ↗

Cell cycle defects in polyhomeotic mutants are caused by abrogation of the DNA damage checkpoint.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.