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Article

Cell cycle defects in polyhomeotic mutants are caused by abrogation of the DNA damage checkpoint.

Developmental biology - 15 Mar 2010

Beck Samantha A, Falconer Ester, Catching Amanda, Hodgson Jacob W, Brock Hugh W

Abstract excerpt

Polycomb group (PcG) genes are required for heritable silencing of target genes. Many PcG mutants have chromatin bridges and other mitotic defects in early embryos. These phenotypes can arise from defects in S phase or mitosis, so the phenotype does not show when PcG proteins act in cell cycle regulation. We analyzed the cell cycle role of the proximal subunit of Polyhomeotic (PhP) in Drosophila. Time-lapse...

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Source

Identifiers

PMID: 20045683
DOI: 10.1016/j.ydbio.2009.12.031

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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