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Article

Mechanistic insights into activation and SOCS3-mediated inhibition of myeloproliferative neoplasm-associated JAK2 mutants from biochemical and structural analyses.

The Biochemical journal - 1 Mar 2014

Varghese Leila N, Ungureanu Daniela, Liau Nicholas P D, Young Samuel N, Laktyushin Artem, Hammaren Henrik, Lucet Isabelle S, Nicola Nicos A, Silvennoinen Olli, Babon Jeffrey J, Murphy James M

Abstract excerpt

JAK2 (Janus kinase 2) initiates the intracellular signalling cascade downstream of cell surface receptor activation by cognate haemopoietic cytokines, including erythropoietin and thrombopoietin. The pseudokinase domain (JH2) of JAK2 negatively regulates the catalytic activity of the adjacent tyrosine kinase domain (JH1) and mutations within the pseudokinase domain underlie human myeloproliferative neoplasms,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Suppressor of Cytokine Signaling 3 Protein

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Source

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Identifiers

PMID: 24354892
DOI: 10.1042/BJ20131516
PMCID: PMC4085142

Genes

JAK2
SOCS3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Mechanistic insights into activation and SOCS3-mediated inhibition of myeloproliferative neoplasm-associated JAK2 mutants from biochemical and structural analyses.PMID 24354892Read ↗

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The molecular regulation of Janus kinase (JAK) activationSemantic proximity Read ↗

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SOCS-mediated downregulation of mutant Jak2 (V617F, T875N and K539L) counteracts cytokine-independent signaling.Semantic proximity Read ↗

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