Article
Prediction of the structure of human Janus kinase 2 (JAK2) comprising the two carboxy-terminal domains reveals a mechanism for autoregulation.
Protein engineering - 1 Jan 2001
Lindauer K, Loerting T, Liedl K R, Kroemer R T
Abstract excerpt
The structure of human Janus kinase 2 (JAK2) comprising the two C-terminal domains (JH1 and JH2) was predicted by application of homology modelling techniques. JH1 and JH2 represent the tyrosine kinase and tyrosine kinase-like domains, respectively, and are crucial for function and regulation of the protein. A comparison between the structures of the two domains is made and structural differences are highlighted....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.