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Article

Structural and Functional Characterization of the JH2 Pseudokinase Domain of JAK Family Tyrosine Kinase 2 (TYK2).

The Journal of biological chemistry - 6 Nov 2015

Min Xiaoshan, Ungureanu Daniela, Maxwell Sarah, Hammarén Henrik, Thibault Steve, Hillert Ellin-Kristina, Ayres Merrill, Greenfield Brad, Eksterowicz John, Gabel Chris, Walker Nigel, Silvennoinen Olli, Wang Zhulun

Abstract excerpt

JAK (Janus family of cytoplasmic tyrosine kinases) family tyrosine kinase 2 (TYK2) participates in signaling through cytokine receptors involved in immune responses and inflammation. JAKs are characterized by dual kinase domain: a tyrosine kinase domain (JH1) that is preceded by a pseudokinase domain (JH2). The majority of disease-associated mutations in JAKs map to JH2, demonstrating its central regulatory...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26359499
DOI: 10.1074/jbc.M115.672048
PMCID: PMC4646372

Genes

TYK2
JAK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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