Article
Long span DNA paired-end-tag (DNA-PET) sequencing strategy for the interrogation of genomic structural mutations and fusion-point-guided reconstruction of amplicons.
PloS one - 1 Jan 2012
Yao Fei, Ariyaratne Pramila N, Hillmer Axel M, Lee Wah Heng, Li Guoliang, Teo Audrey S M, Woo Xing Yi, Zhang Zhenshui, Chen Jieqi P, Poh Wan Ting, Zawack Kelson F B, Chan Chee Seng, Leong See Ting, Neo Say Chuan, Choi Poh Sum D, Gao Song, Nagarajan Niranjan, Thoreau Hervé, Shahab Atif, Ruan Xiaoan, Cacheux-Rataboul Valère, Wei Chia-Lin, Bourque Guillaume, Sung Wing-Kin, Liu Edison T, Ruan Yijun
Abstract excerpt
Structural variations (SVs) contribute significantly to the variability of the human genome and extensive genomic rearrangements are a hallmark of cancer. While genomic DNA paired-end-tag (DNA-PET) sequencing is an attractive approach to identify genomic SVs, the current application of PET sequencing with short insert size DNA can be insufficient for the comprehensive mapping of SVs in low complexity and...
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