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Article

Mapping of MCP-1 functional domains by peptide analysis and site-directed mutagenesis.

FEBS letters - 3 Jul 1998

Steitz S A, Hasegawa K, Chiang S L, Cobb R R, Castro M A, Lobl T J, Yamada M, Lazarides E, Cardarelli P M

Abstract excerpt

Monocyte chemoattractant protein-1 (MCP-1) is a member of the beta chemokine family which acts through specific seven transmembrane receptors to recruit monocytes, basophils, and T lymphocytes to sites of inflammation. To identify regions of the human MCP-1 protein which are important for its biological activity, we have synthesized domain-specific peptides and tested their ability to antagonize MCP-1 binding and...

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Identifiers

PMID: 9688530
DOI: 10.1016/s0014-5793(98)00637-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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