Article
Mapping of MCP-1 functional domains by peptide analysis and site-directed mutagenesis.
FEBS letters - 3 Jul 1998
Steitz S A, Hasegawa K, Chiang S L, Cobb R R, Castro M A, Lobl T J, Yamada M, Lazarides E, Cardarelli P M
Abstract excerpt
Monocyte chemoattractant protein-1 (MCP-1) is a member of the beta chemokine family which acts through specific seven transmembrane receptors to recruit monocytes, basophils, and T lymphocytes to sites of inflammation. To identify regions of the human MCP-1 protein which are important for its bio...
Topics
- Amino Acid Sequence
- Arginine
- Binding, Competitive
- Cell Line
- Chemokine CCL2
- Chemotaxis, Leukocyte
- Humans
- Molecular Sequence Data
- Monocytes
- Mutagenesis, Site-Directed
- Mutation
- Peptides
- Peptides, Cyclic
- Recombinant Fusion Proteins
- Tyrosine