Article
NFKB2 polymorphisms associate with the risk of developing rheumatoid arthritis and response to TNF inhibitors: Results from the REPAIR consortium.
Scientific reports - 9 Mar 2020
Manuel Sánchez-Maldonado Jose, Martínez-Bueno Manuel, Canhão Helena, Ter Horst Rob, Muñoz-Peña Sonia, Moñiz-Díez Ana, Rodríguez-Ramos Ana, Escudero Alejandro, Sorensen Signe B, Hetland Merete L, Ferrer Miguel A, Glintborg Bente, Filipescu Ileana, Pérez-Pampin Eva, Conesa-Zamora Pablo, García Antonio, den Broeder Alfons, De Vita Salvatore, Hove Jacobsen Svend Erik, Collantes Eduardo, Quartuccio Luca, Netea Mihai G, Li Yang, Fonseca João E, Jurado Manuel, López-Nevot Miguel Ángel, Coenen Marieke J H, Andersen Vibeke, Cáliz Rafael, Sainz Juan
Abstract excerpt
This study sought to evaluate the association of 28 single nucleotide polymorphisms (SNPs) within NFKB and inflammasome pathway genes with the risk of rheumatoid arthritis (RA) and response to TNF inhibitors (TNFi). We conducted a case-control study in a European population of 1194 RA patients and 1328 healthy controls. The association of potentially interesting markers was validated with data from the DANBIO...
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