Article
Naturally mutated envelope protein domain I of Chinese B dengue virus attenuated human dendritic cell maturation.
International immunopharmacology - 1 Dec 2012
Li Jiayi, Zhang Xulong, Zuo Li, Shang Zhengling, Sun Rui
Abstract excerpt
Dengue virus (DENV) can infect human dendritic cells (DCs), and cause a spectrum of clinical symptoms. Envelope protein of DENV contains three distinct domains, including domain I (DI), domain II (DII) and domain III (DIII), and plays important roles in receptor binding and induction of protective antibodies. Previously, a new DENV-2 type virus (named B strain) with eight gene mutations in DI of the envelope...
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