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Article

Characterization of the Immunologic Phenotype of Dendritic Cells Infected With Herpes Simplex Virus 1.

Frontiers in immunology - 1 Jan 2022

Zhang Jingjing, Xu Xingli, Duan Suqin, Gao Yang, Ma Danjing, Yue Rong, Zeng Fengyuan, Li Xueqi, Meng Ziyan, Li Xinghang, Niu Zhenye, Jiang Guorun, Yu Li, Liao Yun, Li Dandan, Wang Lichun, Zhao Heng, Zhang Ying, Li Qihan

Abstract excerpt

Due to viral envelope glycoprotein D binding to cellular membrane HVEM receptor, HSV-1 can infect certain dendritic cells, which becomes an event in the viral strategy to interfere with the host's immune system. We previously generated the HSV-1 mutant strain M6, which produced an attenuated phenotype in mice and rhesus monkeys. The attenuated M6 strain was used to investigate how HSV-1 infection of dendritic...

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Identifiers

PMID: 35865514
DOI: 10.3389/fimmu.2022.931740
PMCID: PMC9294641

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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