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Article

Identification of Important N-Linked Glycosylation Sites in the Hemagglutinin Protein and Their Functional Impact on DC-SIGN Mediated Avian Influenza H5N1 Infection.

International journal of molecular sciences - 13 Jan 2021

Yang Zih-Syuan, Huang Szu-Wei, Wang Wen-Hung, Lin Chih-Yen, Wang Chu-Feng, Urbina Aspiro Nayim, Thitithanyanont Arunee, Tseng Sung-Pin, Lu Po-Liang, Chen Yen-Hsu, Wang Sheng-Fan

Abstract excerpt

DC-SIGN, a C-type lectin mainly expressed in dendritic cells (DCs), has been reported to mediate several viral infections. We previously reported that DC-SIGN mediated H5N1 influenza A virus (AIVs) infection, however, the important DC-SIGN interaction with N-glycosylation sites remain unknown. This study aims to identify the optimal DC-SIGN interacting N-glycosylation sites in HA proteins of H5N1-AIVs. Results...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hemagglutinin Glycoproteins, Influenza Virus

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Identifiers

PMID: 33451024
DOI: 10.3390/ijms22020743
PMCID: PMC7828482

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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